Publications

Obesity, Metabolic Dysfunction and Their Negative Impacts on Cancer Treatments

WebMD: Obesity’s Cancer Link Is Worse Than You Think

July 2025: Obesity-associated cancers tripled nationwide over past two decades

Mita et al., 2025, A Phase 1 Safety Study of Evexomostat (SDX-7320) in Patients with Late-Stage Cancer: An Antiangiogenic, Insulin-Sensitizing Drug Conjugate Targeting METAP2

Koylu et al., 2025, The impact of sarcopenic obesity on cancer clinical outcomes

Pati et al., 2023, Obesity and Cancer: A Current Overview of Epidemiology, Pathogenesis, Outcomes, and Management

Marmol et al., 2023, Insulin resistance in patients with cancer: a systematic review and meta-analysis

Perry et al., 2020, Mechanistic Links between Obesity, Insulin, and Cancer

Arrieta et al., 2019, Combination of metformin plus TKI vs. TKI alone in EGFR(+) LUNG adenocarcinoma: A randomized phase II study

Hopkins et al., 2018, Suppression of insulin feedback enhances the efficacy of PI3K inhibitors

Michelet et al., 2018, Metabolic reprogramming of natural killer cells in obesity limits antitumor responses

Murphy et al., 2018, Elevated Leptin during Diet-Induced Obesity Reduces the Efficacy of Tumor Immunotherapy

Aguilar et al., 2018, Obesity induced T cell dysfunction and implications for cancer immunotherapy

Incio et al., 2018, Obesity promotes resistance to anti-VEGF therapy in breast cancer by up-regulating IL-6 and potentially FGF-2 

Wei et al., 2015 The impact of insulin on chemotherapeutic sensitivity to 5-fluorouracil in gastric cancer cell lines SGC7901, MKN45 and MKN28

Obesity and Cancer: Mechanisms Underlying Progression and Metastases

Schmidt et al., 2018, Cancer Cachexia: More Than Skeletal Muscle Wasting

Quail et al., 2018, The obese adipose tissue microenvironment in cancer development and progression

Iyengar et al., 2017, Metabolic Obesity, Adipose Inflammation and Elevated Breast Aromatase in Women with Normal Body Mass Index

Quail et al., 2017, Obesity alters the lung myeloid cell landscape to enhance breast cancer metastasis through IL5 and GM-CSF 

Goodwin et al., 2002, Fasting Insulin and Outcome in Early-Stage Breast Cancer: Results of a Prospective Cohort Study 

Duan at al., 2013, Obesity, adipokines and hepatocellular carcinoma

Morris et al., 2011, Inflammation and Increased Aromatase Expression Occur in the Breast Tissue of Obese Women with Breast Cancer 

Frisch et al., 2015, Non-small cell lung cancer cell survival crucially depends on functional insulin receptors 

Lengyel et al., 2018, Cancer as a Matter of Fat: The Crosstalk between Adipose Tissue and Tumors

Iyengar et al., 2016, Obesity and Cancer Mechanisms: Tumor Microenvironment and Inflammation 

Chettouh et al., 2015, Hyperinsulinaemia and insulin signaling in the pathogenesis and the clinical course of hepatocellular carcinoma 

Chakraborty et al., 2017, Fibroblast growth factor receptor is a mechanistic link between visceral adiposity and cancer 

VanSaun, 2013 Molecular Pathways: Adiponectin and Leptin Signaling in Cancer 

Creighton et al., 2012, A gene transcription signature of obesity in breast cancer 

Nutrition, Exercise and Cancer Outcomes

Schmitz et al, 2017, Transdisciplinary Research on Energetics and Cancer: From Adipose Tissue to the American Society of Clinical Oncology (ASCO) Summit Recommendations 

Koelwyn et al, 2017, Exercise-dependent regulation of the tumour microenvironment 

Jones et al, 2016, Exercise and Risk of Cardiovascular Events in Women with Non-metastatic Breast Cancer

Brown et al, 2018, Dose–response effects of exercise on insulin among colon cancer survivors

de Boer et al, 2017, The Mechanisms and Effects of Physical Activity on Breast Cancer

Visceral Adipose Tissue: Its Role in Cancer Progression and Patient Outcomes

Kane et al., 2019, Innate Immune Control of Adipose Tissue Homeostasis

Dickerman et al., 2019, Body fat distribution on computed tomography imaging and prostate cancer risk and mortality in the AGES‐Reykjavik study

Iwase et al., 2016, Impact of body fat distribution on neoadjuvant chemotherapy outcomes in advanced breast cancer patients 

Lee et al., 2015, Visceral Adiposity is a Risk Factor for Poor Prognosis in Colorectal Cancer patients Receiving Adjuvant Chemotherapy 

Fujiwara et al, 2015, Sarcopenia, intramuscular fat deposition, and visceral adiposity independently predict the outcomes of hepatocellular carcinoma 

Guiu et al, 2009, Visceral fat area is an independent predictive biomarker of outcome after first-line bevacizumab-based treatment in metastatic colorectal cancer 

Moon et al, 2008, Visceral Obesity May Affect Oncologic Outcome in Patients with Colorectal Cancer 

Epidemiology of Obesity and Cancer

Iyengar et al., 2018, Association of Body Fat and Risk of Breast Cancer in Postmenopausal Women With Normal Body Mass Index A Secondary Analysis of a Randomized Clinical Trial and Observational Study

Gu et al., 2019, Association of serum leptin with breast cancer – A meta-analysis

Calle et al., 2003, Overweight, Obesity, and Mortality from Cancer in a Prospectively Studied Cohort of U.S. Adults 

Ligibel et al., 2014, American Society of Clinical Oncology Position Statement on Obesity and Cancer 

Goodwin & Chlebowski, 2016, Obesity and Cancer: Insights for Clinicians 

Lauby-Secretan et al., 2016, Body Fatness and Cancer — Viewpoint of the IARC Working Group 

Fedirko et al., 2014, Pre-diagnostic anthropometry and survival after colorectal cancer diagnosis in Western European populations 

Chan et al., 2014, Body mass index and survival in women with breast cancer—systematic literature review and meta-analysis of 82 follow-up studies 

Niraula et al., 2012, Body size and breast cancer prognosis in relation to hormone receptor and menopausal status: a meta-analysis